Treatment of Secondary Progressive Multiple Sclerosis (SPMS)
SPMS is one of the four universally known types of multiple sclerosis. In this disease form, there is a rapid neurological damage which may be accompanied by relapses and remissions. People with SPMS would have undergone a phase of Relapsing/Remitting Multiple Sclerosis (RRMS) lasting from two to more years. The damage is rapid in this stage of disease but rate of increased disability varies among people.
In the SPMS form, lesions formation is decreased than in RRMS but general deterioration continues. This may be due to greater loss of axonal. SPSS patients form 30% of the total Multiple Sclerosis population. Reasons for progression of disability from the beginning of disease to its secondary state are still not known fully. The advanced forms of MS have not yielded to treatment. The affect of legendary immunosuppresion as a treatment has been at best, meagre. So far, interferons and glatiramer have proved effective. Clinical Results have shown positive effect of these drugs on chronic patients.
In case of MS, the crux lies in overall management of disease. Being a debilitating disease, it causes inconsistent bladder movements, pain, depression, fatigue, sexual dysfunction, tremor, paroxysmal disorders and heat intolerance. A holistic system of disease management may reduce the trauma.
Treatment
Interferon beta-1b is most common treatment for SPMS and has been seen to significantly reduce the progression of disease-linked disability. Interferons help in regulating immune system of the body. In SPMS, it restricts the activities of disease causing white-blood cells. As a result of this medication, there is a significant difference in time between relapses. The size of lesions is also diminished, as a result. It is taken in injectible dose and side effects include flu-like symptoms and reaction around injection area. In certain cases, patients do not respond to interferons. If a patient does not respond to interferon after being treated for 6 months, it is obvious that interferon is not working. The body may have produced neutralizing antibodies to interferon. Another disadvantage is that interferon is an expensive drug. Mitoxantrone is known to restrain certain cells of the body that destroy myelin in central nervous system.
As a result, rate of relapse gets delayed and progression of disability is reduced. Mitoxantrone (Novantrone) has shown effectiveness in PMS although its side effects can cause severe complications. It is a chemotherapy medication and is given intravenously every three month. It can also be given on monthly basis depending on the severity of the disease. The side effects include potential toxicities including cardiac toxicity. A cardiologist’s opinion should be sought before starting the medication of Mitoxantrone.
In addition, muscle relaxants, Anticholiergics, Urinary Tract Antispasmodics, anticonvulsants, central nervous system stimulant, antidepressants; NSAIDS can be used to combat common symptoms of MS.
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